tebu-bio and Cypex Ltd introduce seven new Dog Bactosomes

Oct. 24, 2008 - PRLog -- Dog is an important, widely used species within the pharmaceutical industry for assessing the metabolism, pharmacokinetics, safety, and efficacy of drugs and drug candidates in discovery and development.

These bactosomes are bacterial membranes containing dog cytochrome P450s coexpressed with dog NADPH-cytochrome P450 reductase, from the CYP1A, CYP2B, CYP2C, CYP2D and CYP3A families.

Within these families, particular enzymes have been recognised as being important in dog metabolism: CYP3A12, the major testosterone 6β-hydroxylase, CYP2C21 and CYP2C41. These enzymes have been developed in the bactosomes technology.

We have also developed four other important enzymes: CYP1A1, CYP2B11, CYP2D15 and CYP3A26.

The patented technology underlying Cypex's Bactosomes enables the expression of human and dog metabolising enzymes in bacteria without the need for large modifications to be made to the proteins.

These exciting new products are available throughout Europe from tebu-bio. Further information can be found online at http://adme.tebu-bio.com/

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