Apoptosis 2009: Opportunities in Cancer and Other Diseases-Aarkstore Enterprise

April 8, 2010 - PRLog -- Apoptosis is regarded as the major mode of cell death in cancer and should therefore be considered as a potential target when developing new antineoplastic drugs. An increasing number of companies are doing so, and we anticipate that this approach will pay substantial dividends, both therapeutically and commercially.

This report reviews 370 apoptosis-modulating drug candidates, and reveals a transforming market offering growth potential in cancer and other indications. Apoptosis (programmed cell death) is a natural phenomenon and occurs via a tightly regulated complex signalling cascade. Several major classes of drugs on the market - cancer chemotherapeutics, anti-TNF therapies, glucocorticoids - are now known to work, at least partly and/or indirectly, via apoptosis modulation. In cancer and in other diseases, elements of the apoptotic process become dysregulated, offering many direct targets for drug discovery.


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