Follow on Google News News By Tag Industry News News By Place Country(s) Industry News
Follow on Google News | AnaSpec Offers Industry’s First Anti-MOG ELISA assay kitsMyelin Oligodendrocyte Glycoprotein (MOG), a protein with a molecular weight of 26- to 28-kDa, is a member of the immunoglobulin superfamily.
By: AnaSpec EGT Group Myelin Oligodendrocyte Glycoprotein (MOG), a protein with a molecular weight of 26- to 28-kDa, is a member of the immunoglobulin superfamily. It is expressed exclusively in the central nervous system (CNS), specifically on the surface of myelinating oligodendrocytes and external lamellae of myelin sheath. MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins. However, it has been demonstrated to be a crucial autoantigen for multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys (1-6). These proteins, with sequences corresponding to human, mouse and rat extracellular domain, together with a 6x His tag were expressed in E. coli and purified from urea denatured bacterial lysate. The molecular weight found in all 3 recombinant proteins was 14.23 kDa. These proteins were shown to induce EAE in either mouse (for the human and mouse rMOGs) or rat (for rat rMOG). For more information, please visit https://www.anaspec.com/ References: 1. Linares, D. et al. Protein Expression and Purif. 34, 249 (2004). 2. Bettadapura, J. et al. J. Neurochem. 70, 1593 (1998). 3. Oliver, AR. et al. J. Immunol. 171, 462 (2003). 4. Von Budingen, H-C. et al. J. Clin. Immunol. 21, 155 (2001). 5. Lyons, J-A. et al. Eur. J. Immunol. 29, 3432 (1999). 6. Von Budingen, H-C. et al. Eur. J. Immunol. 34, 2072 (2003). AnaSpec, EGT Group AnaSpec, EGT Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008. For more information visit www.anaspec.com # # # AnaSpec, Inc. is a leading provider of integrated proteomics solutions™ for worldwide life science research. AnaSpec offers expertise in three primary technologies: End
|
|