White Paper Dont Be Thrown off Balance Safer Operations in Biofermentation

Oct. 10, 2012 - PRLog -- Active Pharmaceutical Ingredients (APIs) produced via biofermentation are extremely sensitive to the manufacturing process. Whether continuous or fed-batch mode, biofermentation requires careful control of analytical parameters in order to minimize batch inconsistency and prevent batch loss. The goal is to keep parameters such as pH and dissolved oxygen at a constant level or following a predefined course. However, as a run progresses, cell metabolism and accumula-tion of metabolic side products may alter the fermentation medium in an unpredictable way, necessitating corrective action. Bioreactors on which several analytical parameters are being monitored can be complex for technicians to operate and therefore carry risks of human error.

METTLER TOLEDO's white paper shows how recent developments in process analytics have simplified analytical measurements on bioreactors and reduced the possibility of mistakes being made.

METTLER TOLEDO's Process Analytics division develops and manufactures instrumentation and sensors used for process measurement and control, offering measurements of pH, dissolved and gaseous oxygen, dissolved ozone, turbidity, oxygen reduction potential (ORP), resistivity/conductivity, total organic carbon (TOC) and flow.  METTLER TOLEDO Process Analytics consists of two business units, Ingold and Thornton, whose products are commonly used in industries such as:

• Pharmaceuticals and biotechnology
• Chemical process and refining industries
• Brewing, food and beverage production
• Power and steam generation plants
• Microelectronics manufacturing

For additional information, visit http://www.mt.com/pro?crel=ePR_PP_EN

About Author:
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.