New efficient Reagents for mRNA transfection in classic and Stem cells

MARSEILLE, France - April 23, 2013 - PRLog -- mRNA transfection provides several advantages over plasmid DNA delivery. It does not require nuclear uptake for being expressed since translation of mRNA occurs into cytoplasm. Indeed, nuclear delivery (bypassing nuclear membrane) is one the principal barriers for transfecting slow or non-dividing cells and, consequently, mRNA transfection is particularly attractive for such purpose. Moreover, this approach presents also the advantage of not being integrative. Contrary to DNA, mRNA cannot lead to genetic insertion causing mutations.

Taking into consideration the nucleic acid types, size and function of messenger RNA, Oz Biosciences has developed new specific reagents allowing mRNA transfection with high efficiency. RmesFect™ and RmesFect™ Stem are specifically designed for in vitro mRNA transfection in a large variety of classic and stem cells respectively. The cationic design of these products allows to highly compacting mRNA for an efficient transport directly into the cytosol. In that way, nuclear delivery is no more required for gene expression to be effective.

RmesFect™ and RmesFect™ Stem have been developed for very efficient transfections of mRNA in a wide variety of immortalized and primary cells. These transfection reagents are serum compatible and are used for transient transfections. These products are very stable, and ready-to-use. mRNA transfection is particularly suited for mRNA vaccines, for cell reprogramming or IPs generation, primary cells transfection, regenerative medicine to name a few.

RmesFect™ and RmesFect™ Stem transfection reagents are provided with a comprehensive protocol that contains all information for your classic or stem cells transfection.

About OZ Biosciences:

OZ Biosciences creates, develops and produces unique transfection reagents and transduction tools for the scientific community and pharmaceutical industry. As an innovative technology-based company, OZ Biosciences continually provides enabling technologies for the delivery of biomolecules. Located in the Luminy Scientific Park, the heart of important biological research activity in Marseille, France, the company has established a strong position in the field of molecular delivery systems.