Cancer as a Metabolic Disease by Jeffrey Dach MD

BOCA RATON, Fla. - Jan. 20, 2015 - PRLog -- Chemotherapy kills normal cells as well as cancer cells. The obvious flaw in cancer chemotherapy treatment is the non-specificity.  In other words, cancer chemotherapy kills cancer cells as well as normal cells.  This unwanted toxicity to normal cells accounts for the adverse side effects of chemotherapy, namely nausea, vomiting, loss of appetite, weight loss, bone marrow suppression with anemia, hair loss etc.

Finding a Selective Cancer Treatment, Leaving Normal Cells Unharmed. The optimal cancer treatment is one that kills cancer cells while leaving normal cells unharmed.  Dr Seyfried’s article, “Cancer as a metabolic disease ” points the way to this goal.(1)   Dr. Seyfried says: “cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.“(1)  Electron microscope studies have shown abnormalities in the mitochondria of cancer cells.(2)  The cancer cell’s mitochondria have undergone “metabolic reprogramming”, thereby providing a key which can be exploited to devise a more selective cancer treatment.

Drs Ko and Pederson, 3BP and Hexokinase II

Basic science studies by Drs Ko and Pedeson have uncovered the exact details of the metabolic reprogramming of the mitochondria of cancer cells.  In cancer cells, an embryonic form of Hexokinase called Hexokinase II has been attached to the membrane pores of the mitochondria (called VDAC voltage dependent anion channels) .  Hexokinase II is the first enzyme in glucose utilization and its location on the outer membrane pores allows for the massive utilization of glucose to feed the rapidly growing tumor mass.  Separation of the Hexokinase II from the VDAC pore on the outer mitochondrial membrane triggers apoptosis (programmed cell death) of the cancer cell while sparing normal cells.(5,6)

Discovery of 3BP by Dr. Ko

Drs Ko and Pederson discovered a small molecule called 3BP which throws a “monkey wrench” into the metabolic machinery of the cancer cell, and induces apoptosis via separation of Hexokinase II from the outer mitochondrial membrane. (7)(27, 28)

3BP (3 Bromo Pyruvate) is a small non-toxic molecule that induces apoptosis in cancer cells while sparing normal cells, thus providing the most promising cancer treatment we have seen in many years.  In-fighting (http://www.lewrockwell.com/2014/10/bill-sardi/is-a-cancer...) over patent rights by the key players has delayed drug development and commercialization.  Unfortunately, 3BP as a cancer treatment may never come to fruition. (7)

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Jeffrey Dach MD
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