Post-Menopausal Hormone Replacement Therapy (HRT)

Post-Menopausal HRT Market Forecast to Show Slow Growth until 2018
By: Rajesh Gunnam
 
Aug. 30, 2011 - PRLog -- The global post-menopausal HRT market valued $1.3 billion in 2010, and is forecast to stabilize at a compound annual growth rate (CAGR) of 0.7% over the next eight years, to reach $1.4 billion by 2018.
The HRT market, which is primarily a stagnant market, is currently dominated by oral and topical estrogen formulations. Rising drug prices and an increase in the elderly population to an extent have negated the decrease in the prescription rate of HRT. The decrease in the prescription of HRT is a result of the Women’s Health Initiative (WHI) study, terminated in 2002, which showed an increased risk of severe adverse events including breast cancer, endometrial cancer and stroke in women on HRT. The WHI study affected the entire HRT market during 2002–2005. Doubts still surround the safety of combination HRT, such as Prempro, although the prescription of oral and topical estrogens such as Premarin and Vagifem appears to have stabilized in recent years due to the lower risk of serious adverse events associated with such drugs.

Consequently, patients’ and physicians’ poor acceptance of HRT is a major restraint to the HRT market. A shift towards relatively safer low-dose and ultra-low dose post-menopausal HRT such as Premarin (0.3mg) and Prempro (0.3mg/1.5mg) contributed to the stabilization of the HRT market during 2005–2010. Furthermore, the launch of Pfizer’s Aprela in 2012, which is a combination of conjugated estrogens (CE) and bazedoxifene (BZA), is expected to positively impact the valuations of the HRT market.

GlobalData’s research indicates that current competition in the post-menopausal HRT market is weak.
Several products are currently available in different dosages such as oral tablets, vaginal creams, rings
and tablets, sprays, syringes, and combination products. HRT has been the treatment of choice since the
1960s; however it is associated with serious safety issues, such as increased risk of breast cancer (26%)
and cardiovascular disease (41%). In addition, the widespread media coverage received by the results of
the WHI study caused a fear among both women and physicians. Low-dose and ultra-low dose versions
of hormones used for a short duration have reduced the unmet need to a marginal extent, however there is limited data supporting the safety of these reduced doses of HRT. As a result, the current postmenopausal HRT market requires a product with a significantly better safety profile than the currently marketed treatments.

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HRT is among the most efficacious pharmacological interventions for the treatment of post-menopausal
symptoms and osteoporosis. However, it is associated with serious side effects such as the increased risk
of cancer and coronary heart disease. The 2002 WHI study significantly and negatively affected the postmenopausal HRT market and led to increased concerns among HRT patients. Despite the 2007 WHI reanalysis, which suggested that HRT is not as harmful as originally thought, concerns among postmenopausal women regarding the use of HRT still exist.

GlobalData, the industry analysis specialist, has released its new report, “Post-Menopausal Hormone
Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018”. The report is an essential source of information and analysis on the global Hormone Replacement Therapy in Menopause Therapeutics market. The report identifies the key trends shaping and driving the global Hormone Replacement Therapy in Menopause Therapeutics market. The report also provides insights on the prevalent competitive landscape and the emerging players expected to significantly alter the market positioning of the current market leaders. Most importantly, the report provides valuable insights on the pipeline products within the global Hormone Replacement Therapy in Menopause Therapeutics sector. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData’s team of industry experts.

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Source:Rajesh Gunnam
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Tags:Hormone Replacement Therapy, Post Menopausal, Pharmaceuticals_and_healthcare
Industry:Health
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