Importance of Edotoxin Testing in Hemodialysis PROCEDURE

Oct. 27, 2012 - PRLog -- Water used for haemodialysis should be tested routinely to verify the efficacy of the disinfection programme, Disinfection is a less lethal process than sterilization, since it is expected to destroy most recognized pathogenic microorganisms, but not
necessarily all those present. Disinfection does not eliminate endotoxin,  it is stable, it is not easily destroyed by sanitizers , Only ultrafiltration  removes endotoxin.  

The LAL assay is the method recommended for endotoxin testing by the most Pharmacopoeias, and is widely used  the pharmaceutical industry.

All the established techniques (gel-clot, turbidimetric and chromogenic) for LAL testing can be used for testing water for haemodialysis.

The LAL gel-clot test and Chromogenic Endpoint assay can be perfomed very  easily in  a dialysis unit. The suppliers of the LAL reagent will normally provide training in the testing and validation procedures.

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