Amino Acid Tripeptide Dr.kumar Pati, Hayward, Usa

HAYWARD, Calif. - June 17, 2013 - PRLog -- L-Glutathione Reduced is a biologically active sulfur amino acid tripeptide compound that contains three amino acids, L-Cysteine, L-Glutamic Acid, and Glycine.

The primary biological function of glutathione is to act as a non-enzymatic reducing agent to help keep cysteine-thiol side chains in a reduced state on the surface of proteins.  Reduced glutathione is involved in the synthesis and repair of DNA.  It helps to recycle vitamins C and E, as well as block free radical damage to enhance the antioxidant activity of vitamin C.  Also, it is the base material for several other key antioxidant enzyme systems, including glutathione-peroxidase, glutathione-reductase, and glutathione-transferase.  Amino acids transport is facilitated by glutathione, and it also plays a critical role in the detoxification of harmful compounds.  Intracellular fluids that show a decline in glutathione concentrations correlate directly with indicators of aging.

Glutathione cannot be obtained directly from food constituents, but these levels are enhanced through the intake of vitamin C.  A daily dose of 500 mg vitamin C may be adequate to elevate and maintain reduced glutathione concentrations in the blood.  In contract, direct consumption of glutathione orally does not seem to be an effective means of enhancing liver and intracellular glutathione levels.

A small study conducted by Witschi et al, using several human subjects concluded that “because of hydrolysis of glutathione in the liver where it detoxifies many harmful compounds to be excreted thru the file.  Some glutathione can also be found in red and white blood cells, the lungs, and the intestinal tract.  Intestinal and hepatic gamma-glutamyitransferase, dietary glutathione is not a major determinant of circulating glutathione”.  Circulating glutathione could not be increased to provide beneficial effects via oral administration of supplemental glutathione of 3 grams, interestingly, intravenous glutathione administration may provide a direct and more effective route for increasing intracellular glutathione levels.   Evidence indicates that oral consumption of N-Acetyl Cysteine may also be an effective means of enhancing these levels, but further research is required to determine the safety and effectiveness.

Through glutathione is undoubtedly a potent antioxidant, indications for its use as a supplement are not yet well established.  There is preliminary evidence that might eventually prove to be useful in the management of some cancers, atherosclerosis, diabetes, lung disorders, noise-induced hearing loss, male infertility, and prevent or ameliorate various toxicities.  It has been an orphan drug for the treatment of AIDS-associated cachexia, and may also have some antiviral activity.

Glutathione is available as a single ingredient dietary supplement, or in combination products.  Daily dosage ranges from 50 to 600 milligrams.