Brochure on Blood Group Products, Manufactured By Dextra, Available from MoBiTec as PDF Download

GÖTTINGEN, Germany - April 28, 2015 - PRLog -- The discovery of the ABO blood typing system by Karl Landsteiner over 100 years ago and the subsequent elucidation of their carbohydrate structures by Walter Morgan were exceedingly important milestones in the progression of modern medicine. The ABO is system is the most important of the many blood typing systems and is of the utmost importance in transfusion and transplantation medicine. If patients receive a transfusion of incompatible blood, an acute haemolytic reaction can occur, this can lead to death.

The blood group antigens are oligosaccharides expressed on the surface of red blood cells and are determined by the terminal saccharides. The biosynthesis is effected via the action of the A or B glycosyltransferase on the H antigen, to form the A or B glycan. The H antigen remains unmodified in individuals lacking either of these glycosyltransferases, resulting in an individual with blood type O. The expression of these antigens is not limited to red blood cells and also occurs on epithelial and other cells.

Blood groups are determined by the ABO gene, which encodes the glycosyltransferase which forms the A, B and H antigens. The alleles for the A and B blood types show co-dominance, whilst the blood group O allele is recessive, giving rise to the familiar 4 ABO blood types.

MoBiTec's partner Dextra, UK, has proven expertise in the manufacture of a wide variety of blood group products, from the standard blood group oligosaccharides, to those functionalized with a selection of linker arms. To complement the free sugar range Dextra also has the capability to produce these antigens as bioconjugates to a range of solid supports, proteins and lipids.

Dextra's Blood Group Products

• Affinity Columns

• Blood Group A

• Blood Group and Lewis Antigen Neoglycolipids

• Blood Group and Lewis Antigen Neoglycoproteins

• Blood Group B

• Blood Group H

• Lewis Antigens

Dextra’s brochure on Blood Group Products (PDF) (http://www.mobitec.com/cms/download/Handbooks/Dextra_Bloo...)

There are several applications for the use of our range of blood group products, for example, the blood group antigens can be used in applications for ABO incompatible transplantation, plasma purification, antibody and recombinant protein purification, and quality control products.

Dextra has developed analytical methodology to support the manufacture and assure the quality of these products. They have a proven track record in scaling processes from milligram up to several kilograms through to cGMP manufacture of APIs in their state of the art, class 100,000 clean rooms. Dextra has successfully achieved ISO9001:2008 registration for all our activities.

About MoBiTec GmbH

MoBiTec GmbH (Goettingen, Germany) is a privately held company (founded in 1987) that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.

In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.

http://www.mobitec.com