Creative Biostructure Supplies MagHelix™ Zebrafish Screening Platform for Drug Discovery

SHIRLEY, N.Y. - Dec. 16, 2021 - PRLog -- Creative Biostructure, a biotechnology company specialized in structural science field, applies its expertise in structural biology and membrane proteins to the drug discovery process and has established ultimate platforms for structure accelerated drug discovery. This newly established MagHelix™ Zebrafish Screening Platform (https://drug-discovery.creative-biostructure.com/maghelix-zebrafish-screening-platform-p43) is an excellent choice for building disease models and screening drugs.

Zebrafish (Danio rerio) possesses the physiological complexity of mammals and is one of the most common vertebrate model organisms. Zebrafish is an excellent choice to model various diseases and screening new drugs for medical and therapeutic research. Zebrafish larvae have been increasingly used to assess the effects of compounds in the past decade.

Backed by abundant experience and cutting-edge facilities, Creative Biostructure provides an ultimate MagHelix™ Zebrafish Screening Platform, which is designed to evaluate the activity and toxicity of compounds of drug development.

There are four classes of zebrafish chemical screening assays:

• Morphological screens (to screen chemical genetics and toxicology)
• Behavioral screens (ex. using swimming kinetics to quantify the effects of single compounds)
• Fixed time-point/labeling assays (to obtain information on a cellular or tissue level)
• Fluorescence assays (reporter-based quantifications)

Creative Biostructure's Advantages:

• A high genetic homology (>85%) to humans as well as their significant similarities in organogenesis and functional mechanisms
• Permeability to small molecules
• Small size (easy to manipulate)
• High fecundity (a large number of samples can be obtained)
• Transparent embryo and larvae (to facilitate noninvasive imaging and massive phenotype-based screening)

"Our experienced scientists can generate various transgenic zebrafish models for human diseases (CNS disorders, skeletal diseases, cardiovascular diseases, etc.) and perform more than 20 assays (angiogenesis assay, toxicity tests, etc.) using our MagHelix™ Zebrafish Screening Platform." Said Joanna, the chief marketing staff at Creative Biostructure.

If you feel interested and want to know more information about the MagHelix™ Zebrafish Screening Platform offered by Creative Biostructure, please visit https://drug-discovery.creative-biostructure.com/maghelix-zebrafish-screening-platform-p43.