Personalized treatment of malignant tumours according to Ki67

KREMS, Austria - June 26, 2024 - PRLog -- The nuclear protein Ki67 is a meaningful biomarker for tumour aggressiveness and for the success of surgical therapy in pleural mesothelioma, a malignant disease of the pleura. This is the clear and promising result of an international study now published by Karl Landsteiner University of Health Sciences (KL Krems) in collaboration with Gazi University, Ankara, Turkey. The study compared the survival rates and overall survival of patients with high and low expression of Ki67 in tumour tissue. It was found that low expression was associated with significantly better prognosis and a better response to surgery for those affected.

Pleural mesothelioma is an aggressive tumour of the pleura, a tissue that surrounds the lungs. It is often triggered by exposure to asbestos, but other causes are also known. Its diagnosis and treatment remain a major challenge, and the prognosis for those affected is still not good. Biomarkers that allow the characterization of individual tumours would help. However, even the few candidates that have been considered so far are not yet sufficiently established for everyday clinical use. Now a study by KL Krems is attracting widespread attention. It shows that the extent of expression of the cell nucleus protein Ki67 makes it possible to draw conclusions about the aggressiveness of the tumour and the prospects of success of certain treatment strategies.

Original publication: Ki67 Tumour Expression Predicts Treatment Benefit Achieved by Macroscopic Radical Lung-Preserving Surgery in Pleural Mesothelioma-A Retrospective Multicenter Analysis. S. Hintermair, S. Iser, A. Varga, M. Biesinger, T. Bohanes, A. Celik, M. Sayan, A. Kankoç, N. Akyurek, B. Öğüt, E. Stubenberger, B. Ghanim. Cancers, Volume 16, Issue 10, May 2024, DOI 10.3390/cancers16101817. Link to the publication: https://kris.kl.ac.at/en/publications/ki67-tumour-expression-predicts-treatment-benefit-achieved-by-macr

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