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Follow on Google News | ![]() A Newly Discovered Molecular Pathway Gives Hope for Overcoming Challenges in the Treatment of CancerBy: Koç University A recent article published in Nature however, reveals an important molecular mechanism that can make a change in this process. The research led by Dr. Serkan Kır from Koç University in Istanbul, illustrates how the activation of EDA2R signalling promotes skeletal muscle atrophy and how the deletion of either EDA2R or the enzyme NIK, can be an effective way to protect the organism from muscle loss. In the article along with Şevval Nur Bilgiç and Aylin Domaniku, Dr. Serkan Kır identifies these novel molecular targets for anti-cachexia therapy. Dr. Serkan Kır's laboratory at the Department of Molecular Biology and Genetics in Koç University utilizes molecular biology approaches, primary cell culture techniques, mouse tumor models and human tissue samples to dissect molecular mechanisms behind tumor signaling to adipose and muscle tissues. With their recent article, "EDA2R–NIK signalling promotes muscle atrophy linked to cancer cachexia", the researchers arrived at a conclusion that targeting the these pathways may be a potential solution in preventing muscle loss. The fact that the activities of the components of this molecular pathway can be altered by drug usage indicates a strong potential for treatment. The research team believes that this newly discovered molecular pathway could also play a role in complications leading to muscle loss beyond cachexia. Treatments for muscular dystrophy diseases and age-related muscle loss (sarcopenia) https://www.nature.com/ https://doi.org/ End
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